Summary: Myofibroblasts are responsible for scarring during fibrosis.The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell state and increasing profibrotic phenotype.Here, we show mechanical stress from progressive scarring induces nuclear softening and de-repression of heterochromatin.The parallel loss of H
Objective: To assess the involvement of the hallux interphalangeal (IP) joint after first metatarsophalangeal joint rail cover (MTPJ) arthrodesis and propose a treatment consisting of MTPJ resection arthroplasty associated with phalangeal osteotomy or IP joint arthrodesis.Methods: We retrospectively analyzed 9 patients treated with MTPJ resection a
Controversy has surrounded Maurice Blanchot from the 1980s to today.Whilst claims of excessive formalism, obscurity and radicalism were often levelled at his generation, the Blanchot Straining Bag controversy has been sustained by the failure of critics to dispassionately appraise his 1930s political commitments.However, recent interventions by Jea
Reports of the incidence of acute kidney injury in patients with coronavirus disease 2019 (COVID-19) have varied greatly from 0.5% to as high as 39%, with onset generally within 7 days from Cold Brew Glass time of admission.The nature of the kidney insult is acute tubular necrosis, immune cell infiltration, or rhabdomyolysis, as demonstrated in aut
Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections.The killer immunoglobulin-like receptors (KIR) and Cat Litter Boxes their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnershi